Cyclerion Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of sGC pharmacology to discover, develop and commercialize breakthrough treatments for serious and orphan diseases. Lead programs include its vascular-targeted olinciguat in Phase 2 development for sickle cell disease and IW-6463, a pioneering CNS-penetrant sGC stimulator in clinical development for Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like episodes (MELAS) and Alzheimer's Disease with Vascular pathology (ADv)
Cyclerion Therapeutics
BioAtla
BioAtla® is a biotech company developing novel monoclonal antibody and cell based therapeutics using their proprietary Conditionally Active Biologics™ (CAB) and Comprehensive Integrated Antibody Optimization (CIAO!™) platforms. These and other proprietary technologies (protected by more than 150 issued patents and patent applications) allow the company to develop novel biologics (CABs) that are better drugs in multiple ways, including more selective targeting of cancer tissue and improved manufacturability. Improved selectivity for the tumor microenvironment (TME), even when the target is also found in normal tissue, not only improves safety and thus therapeutic index, but also expands the universe of potential drug targets, enabling the treatment of previously untreatable cancers.
Curzion Pharmaceuticals
Curzion Pharmaceuticals is a clinical-stage company, co-founded by Pappas Capital, focused on developing treatments for rare fibrotic diseases. The company's lead asset is a potent and selective LPAR1 antagonist for the treatment of diffusive systemic sclerosis.
Allievex
Allievex is a clinical‐stage biotechnology company founded by Pappas Capital that is developing novel therapies for the treatment of rare pediatric neurodegenerative diseases. Allievex’s lead product candidate is tralesinidase alfa, an investigational enzyme replacement therapy using a novel fusion of recombinant human alpha‐N‐acetyglucosaminidase (NAGLU) with a peptide derived from insulin‐like growth factor 2 (IGF2) for the treatment of children with Sanfilippo syndrome type B or mucopolysaccharidosis IIIB (MPS IIIB).
Ribometrix
Ribometrix is a biotechnology company developing small molecule therapeutics that directly target RNA to treat human diseases. The Ribometrix team leverages its world-leading expertise in 3D structural analysis of RNA to drive its discovery platform, drawing on technologies invented in the laboratory of Ribometrix scientific founder Kevin Weeks, Ph.D.
Mirum Pharmaceuticals
Mirum Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to transforming the treatment of rare diseases affecting children and adults. Mirum has three approved medications: LIVMARLI® (maralixibat) oral solution, Cholbam® (cholic acid) capsules, and Chenodal® (chenodiol) tablets.
VelosBio
VelosBio Inc. is a near-term clinical-stage biopharmaceutical company focused on novel cancer targets.
AgTech Accelerator Corporation
AgTech Accelerator Corporation is a venture development organization focused on discovering and developing emerging agricultural technology and animal health companies. Based in Research Triangle Park, NC, AgTech Accelerator identifies, forms, finances and manages emerging agriculture companies to drive commercialization. In addition to its investment in AgTech Accelerator, Pappas Capital has also invested directly in such AgTech Accelerator portfolio companies as Boragen, developing a novel synthetic chemistry platform, initially focusing on next-generation fungicides aimed to mitigate pest resistance and allow for more sustainable farming methods and Skyline Vet Pharma, a veterinary pharmaceutical company.
Research Triangle Ventures
Research Triangle Ventures, a venture capital firm, specialized in investing in seed and early stage technology companies located in North Carolina.
